Upstream Bio Inc (UPB)

Upstream Bio, Inc. is a clinical-stage biotechnology company focused on developing therapies for inflammatory diseases, with an emphasis on severe respiratory disorders. Its lead product candidate, verekitug, is being evaluated in Phase 2 studies for severe asthma, chronic rhinosinusitis with nasal polyps, and chronic obstructive pulmonary disease, and is also in a Phase I trial for chronic obstructive pulmonary disease. Founded in 2021, the company is headquartered in Waltham, Massachusetts. Upstream Bio’s common stock is listed on the NASDAQ under the symbol UPB.


Jump directly to the stock analysis sections supported by the latest available data.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Dividend Yield Next Earnings Date Price-to-Book Ratio Price-to-Sales Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Free Cash Flow / Net Income
NASDAQ-UPB
$6.14
15.0% Upside
Fair
$31.14
483.2% Upside
Bargain
Fair
0.0%
November 5, 2026
1.1x
92.6x
293.6 M
32.124 M
0.3%
78.2%
14.2
87.2%
Valuation • Fair Value

Upstream Bio Inc (NASDAQ-UPB) Fair Value by Valuation Model

Review the available estimates for Upstream Bio Inc (NASDAQ-UPB), including EPV Fair Value, Comps Fair Value.

Primary Valuation Read

Fair Value

$6.14

Estimated upside of 15.0% versus the current market price.

Fair Value Confidence

Very low

Confidence level for the primary fair value estimate.

EPV Fair Value

$7.18

Earnings power value estimate.

Comps Fair Value

$5.97

Comparable-company valuation reference.

Analyst Price Target

$31.14

Analysts imply upside of 483.2%.

How to read these valuation models

Use the 5 available valuation references for Upstream Bio Inc (NASDAQ-UPB) as analytical inputs, not a standalone conclusion. Valuation methods can differ because they rely on different assumptions, time horizons and financial inputs; compare the estimates with the current price and the company’s financial quality.

Profitability • Growth

Profitability & Growth for Upstream Bio Inc (NASDAQ-UPB)

Review the profitability and growth indicators currently supported by the latest data.

Revenue

3.158 M

Current operating scale indicator.

Revenue Forecast

3.353 M

Forward revenue estimate.

EBITDA

-169.8 M

Current operating profitability reference.

EBITDA Forecast

-171.9 M

Forward operating profitability estimate.

How to read profitability and growth

This section helps investors review Upstream Bio Inc (NASDAQ-UPB) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Upstream Bio Inc (NASDAQ-UPB)

Review the financial quality and risk indicators currently supported by the latest data.

Financial Health

Fair

Mixed or neutral financial-health read.

Piotroski Score

2

Weak quality score that deserves closer review.

Beneish M-Score

-2.93

No elevated caution signal from this screen.

Altman Z-Score

14.2

Relatively strong balance-sheet zone.

FCF / Net Income

87.2%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Upstream Bio Inc (NASDAQ-UPB). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Upstream Bio Inc (NASDAQ-UPB)

Track the upcoming dates and dividend metrics currently supported by the latest data.

Next Earnings Date

November 5, 2026

Days to Earnings

48

Dividend Yield

0.0%

No current dividend yield is indicated.

How to read events and dividends

This section helps investors track time-sensitive items for Upstream Bio Inc (NASDAQ-UPB), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Upstream Bio Inc (NASDAQ-UPB) Stock Forecast & Technical Outlook

Review Upstream Bio Inc (NASDAQ-UPB) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Neutral

The 15-minute technical read for Upstream Bio Inc (NASDAQ-UPB) is currently Neutral. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Neutral

The 1-hour technical read for Upstream Bio Inc (NASDAQ-UPB) is currently Neutral. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Strong Sell

The daily technical read for Upstream Bio Inc (NASDAQ-UPB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Strong Sell

The weekly technical read for Upstream Bio Inc (NASDAQ-UPB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Strong Sell

The monthly technical read for Upstream Bio Inc (NASDAQ-UPB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Upstream Bio Inc (NASDAQ-UPB)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Buy

Based on the available recommendation mix, Upstream Bio Inc (NASDAQ-UPB) has a Buy consensus, with 4 buy, 2 hold and 0 sell recommendations in the current data set.

Buy 4
Hold 2
Sell 0
FAQ Fast Investor Answers

Upstream Bio Inc (NASDAQ-UPB) Stock FAQ

Data-supported answers about Upstream Bio Inc (NASDAQ-UPB), including explicit coverage status where a reliable valuation estimate is not currently available.

Fair Value
$6.14
Estimated upside 15.0%
Valuation Rating
Undervalued
Estimated upside of 15.0%
Analyst Target
$31.14
Implied upside 483.2%
Financial Health
Fair
Current financial-health read

The current fair value estimate for Upstream Bio Inc (NASDAQ-UPB) is $6.14. This implies an estimated upside of 15.0% versus the current market price.

Based on the current fair value estimate, the stock appears undervalued, with estimated upside of 15.0% versus the current market price.

The available analyst price target for Upstream Bio Inc (NASDAQ-UPB) is $31.14. The analyst target implies estimated upside of 483.2%.

The current financial health read for Upstream Bio Inc (NASDAQ-UPB) is Fair. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Upstream Bio Inc (NASDAQ-UPB) is November 5, 2026.

The latest available data indicates no current dividend yield for Upstream Bio Inc (NASDAQ-UPB).

The current market capitalization listed for Upstream Bio Inc is 293.6 M.

The current enterprise value listed for Upstream Bio Inc is 32.124 M. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Upstream Bio Inc is NASDAQ-UPB, and the stock is listed on NASDAQ.

Upstream Bio Inc (NASDAQ-UPB) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Upstream Bio Inc is 0.3%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Upstream Bio Inc is 78.2%. Free float helps investors understand how much of the share base is available for public trading.