Ionis Pharmaceuticals Inc (IONS)

Ionis Pharmaceuticals, Inc. is a commercial-stage biotechnology company focused on RNA-targeted medicines in the United States. Its marketed products include TRYNGOLZA for adults with familial chylomicronemia syndrome and acute pancreatitis risk, DAWNZERA for hereditary angioedema prevention, WAINUA for hereditary transthyretin-mediated amyloidosis polyneuropathy, SPINRAZA for spinal muscular atrophy, QALSODY for amyotrophic lateral sclerosis, TEGSEDI for ATTRv-PN, and WAYLIVRA for familial chylomicronemia syndrome and familial partial lipodystrophy. The company also has a development pipeline that includes late-stage candidates such as Olezarsen, Zilganerse, and ION582, along with additional investigational programs including Eplontersen, Pelacarsen, Bepirovirsen, Sefaxersen, and Ulefnersen. Ionis maintains strategic collaborations with Biogen and licensing or collaboration agreements with GSK, AstraZeneca, Novartis, Roche, and Metagenomi. Incorporated in 1989 and headquartered in Carlsbad, California, Ionis trades on NASDAQ as common stock under the ticker IONS.


Jump directly to the stock analysis sections supported by the latest available data.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Dividend Yield Next Earnings Date Price-to-Book Ratio Price-to-Sales Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Free Cash Flow / Net Income
NASDAQ-IONS
$39.74
-10.6% Downside
Fair
$83.82
88.6% Upside
Bargain
Fair
0.0%
November 4, 2026
17.7x
8.9x
7.385 B
7.856 B
22.0%
99.2%
1.0
99.2%
Valuation • Fair Value

Ionis Pharmaceuticals Inc (NASDAQ-IONS) Fair Value by Valuation Model

Review the available estimates for Ionis Pharmaceuticals Inc (NASDAQ-IONS), including DCF Fair Value, Comps Fair Value.

Primary Valuation Read

Fair Value

$39.74

Estimated downside of 10.6% versus the current market price.

Fair Value Confidence

Med

Confidence level for the primary fair value estimate.

DCF Fair Value

$28.11

Discounted cash flow valuation reference.

Comps Fair Value

$43.62

Comparable-company valuation reference.

Analyst Price Target

$83.82

Analysts imply upside of 88.6%.

How to read these valuation models

Use the 5 available valuation references for Ionis Pharmaceuticals Inc (NASDAQ-IONS) as analytical inputs, not a standalone conclusion. Valuation methods can differ because they rely on different assumptions, time horizons and financial inputs; compare the estimates with the current price and the company’s financial quality.

Profitability • Growth

Profitability & Growth for Ionis Pharmaceuticals Inc (NASDAQ-IONS)

Review the profitability and growth indicators currently supported by the latest data.

Revenue

874.1 M

Current operating scale indicator.

Revenue Forecast

898 M

Forward revenue estimate.

EBITDA

-579.5 M

Current operating profitability reference.

EBITDA Forecast

-607.3 M

Forward operating profitability estimate.

How to read profitability and growth

This section helps investors review Ionis Pharmaceuticals Inc (NASDAQ-IONS) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Ionis Pharmaceuticals Inc (NASDAQ-IONS)

Review the financial quality and risk indicators currently supported by the latest data.

Financial Health

Fair

Mixed or neutral financial-health read.

Piotroski Score

2

Weak quality score that deserves closer review.

Beneish M-Score

-3.57

No elevated caution signal from this screen.

Altman Z-Score

1.0

Lower score that deserves closer risk review.

FCF / Net Income

99.2%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Ionis Pharmaceuticals Inc (NASDAQ-IONS). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Ionis Pharmaceuticals Inc (NASDAQ-IONS)

Track the upcoming dates and dividend metrics currently supported by the latest data.

Next Earnings Date

November 4, 2026

Days to Earnings

47

Dividend Yield

0.0%

No current dividend yield is indicated.

How to read events and dividends

This section helps investors track time-sensitive items for Ionis Pharmaceuticals Inc (NASDAQ-IONS), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Ionis Pharmaceuticals Inc (NASDAQ-IONS) Stock Forecast & Technical Outlook

Review Ionis Pharmaceuticals Inc (NASDAQ-IONS) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Strong Sell

The 15-minute technical read for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Strong Sell

The 1-hour technical read for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Strong Sell

The daily technical read for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Strong Sell

The weekly technical read for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Strong Sell

The monthly technical read for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Ionis Pharmaceuticals Inc (NASDAQ-IONS)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Buy

Based on the available recommendation mix, Ionis Pharmaceuticals Inc (NASDAQ-IONS) has a Buy consensus, with 9 buy, 5 hold and 0 sell recommendations in the current data set.

Buy 9
Hold 5
Sell 0
FAQ Fast Investor Answers

Ionis Pharmaceuticals Inc (NASDAQ-IONS) Stock FAQ

Data-supported answers about Ionis Pharmaceuticals Inc (NASDAQ-IONS), including explicit coverage status where a reliable valuation estimate is not currently available.

Fair Value
$39.74
Estimated downside 10.6%
Valuation Rating
Overvalued
Estimated downside of 10.6%
Analyst Target
$83.82
Implied upside 88.6%
Financial Health
Fair
Current financial-health read

The current fair value estimate for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is $39.74. This implies an estimated downside of 10.6% versus the current market price.

Based on the current fair value estimate, the stock appears overvalued, with estimated downside of 10.6% versus the current market price.

The available analyst price target for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is $83.82. The analyst target implies estimated upside of 88.6%.

The current financial health read for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is Fair. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Ionis Pharmaceuticals Inc (NASDAQ-IONS) is November 4, 2026.

The latest available data indicates no current dividend yield for Ionis Pharmaceuticals Inc (NASDAQ-IONS).

The current market capitalization listed for Ionis Pharmaceuticals Inc is 7.385 B.

The current enterprise value listed for Ionis Pharmaceuticals Inc is 7.856 B. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Ionis Pharmaceuticals Inc is NASDAQ-IONS, and the stock is listed on NASDAQ.

Ionis Pharmaceuticals Inc (NASDAQ-IONS) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Ionis Pharmaceuticals Inc is 22.0%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Ionis Pharmaceuticals Inc is 99.2%. Free float helps investors understand how much of the share base is available for public trading.