Denali Therapeutics Inc (DNLI)

Denali Therapeutics Inc. is a NASDAQ-listed biopharmaceutical company focused on developing therapies for neurodegenerative and lysosomal storage diseases. Its pipeline includes programs such as Eclitasertib (SAR443122/DNL758) for peripheral inflammatory diseases, BIIB122/DNL151 for Parkinson’s disease, TAK-594/DNL593 for frontotemporal dementia-granulin, DNL126 for MPS IIIA, and DNL310 Tividenofusp alfa for MPS II. The company also advances Enzyme TransportVehicle programs including DNL952 for Pompe disease, DNL111 for Parkinson’s and Gaucher diseases, and DNL622 for Hurler syndrome, along with OTV candidates such as DNL628 for Alzheimer’s disease and DNL422 for Parkinson’s disease. An antibody TV program, DNL921, targets Abeta in Alzheimer’s disease. Founded in 2013 and based in South San Francisco, California, the company was formerly known as SPR Pharma Inc. before adopting its current name in March 2015.


Jump directly to the stock analysis sections supported by the latest available data.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Dividend Yield Next Earnings Date Price-to-Book Ratio Price-to-Sales Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Free Cash Flow / Net Income
NASDAQ-DNLI
$23.66
9.5% Upside
Fair
$36.06
67.0% Upside
Bargain
Weak
0.0%
November 11, 2026
3.9x
907.9x
3.453 B
2.37 B
1.1%
97.0%
2.7
85.5%
Valuation • Fair Value

Denali Therapeutics Inc (NASDAQ-DNLI) Fair Value by Valuation Model

Review the available estimates for Denali Therapeutics Inc (NASDAQ-DNLI), including DCF Fair Value, Comps Fair Value.

Primary Valuation Read

Fair Value

$23.66

Estimated upside of 9.5% versus the current market price.

Fair Value Confidence

Med

Confidence level for the primary fair value estimate.

DCF Fair Value

$39.08

Discounted cash flow valuation reference.

Comps Fair Value

$15.95

Comparable-company valuation reference.

Analyst Price Target

$36.06

Analysts imply upside of 67.0%.

How to read these valuation models

Use the 5 available valuation references for Denali Therapeutics Inc (NASDAQ-DNLI) as analytical inputs, not a standalone conclusion. Valuation methods can differ because they rely on different assumptions, time horizons and financial inputs; compare the estimates with the current price and the company’s financial quality.

Profitability • Growth

Profitability & Growth for Denali Therapeutics Inc (NASDAQ-DNLI)

Review the profitability and growth indicators currently supported by the latest data.

Revenue

3.604 M

Current operating scale indicator.

Revenue Forecast

33.361 M

Forward revenue estimate.

EBITDA

-526.1 M

Current operating profitability reference.

EBITDA Forecast

-516.7 M

Forward operating profitability estimate.

How to read profitability and growth

This section helps investors review Denali Therapeutics Inc (NASDAQ-DNLI) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Denali Therapeutics Inc (NASDAQ-DNLI)

Review the financial quality and risk indicators currently supported by the latest data.

Financial Health

Weak

Financial pressure deserves closer review.

Piotroski Score

2

Weak quality score that deserves closer review.

Altman Z-Score

2.7

Intermediate risk zone.

FCF / Net Income

85.5%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Denali Therapeutics Inc (NASDAQ-DNLI). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Denali Therapeutics Inc (NASDAQ-DNLI)

Track the upcoming dates and dividend metrics currently supported by the latest data.

Next Earnings Date

November 11, 2026

Days to Earnings

50

Dividend Yield

0.0%

No current dividend yield is indicated.

How to read events and dividends

This section helps investors track time-sensitive items for Denali Therapeutics Inc (NASDAQ-DNLI), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Denali Therapeutics Inc (NASDAQ-DNLI) Stock Forecast & Technical Outlook

Review Denali Therapeutics Inc (NASDAQ-DNLI) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Strong Buy

The 15-minute technical read for Denali Therapeutics Inc (NASDAQ-DNLI) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Strong Buy

The 1-hour technical read for Denali Therapeutics Inc (NASDAQ-DNLI) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Sell

The daily technical read for Denali Therapeutics Inc (NASDAQ-DNLI) is currently Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Strong Sell

The weekly technical read for Denali Therapeutics Inc (NASDAQ-DNLI) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Neutral

The monthly technical read for Denali Therapeutics Inc (NASDAQ-DNLI) is currently Neutral. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Denali Therapeutics Inc (NASDAQ-DNLI)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Strong Buy

Based on the available recommendation mix, Denali Therapeutics Inc (NASDAQ-DNLI) has a Strong Buy consensus, with 17 buy, 1 hold and 0 sell recommendations in the current data set.

Buy 17
Hold 1
Sell 0
FAQ Fast Investor Answers

Denali Therapeutics Inc (NASDAQ-DNLI) Stock FAQ

Data-supported answers about Denali Therapeutics Inc (NASDAQ-DNLI), including explicit coverage status where a reliable valuation estimate is not currently available.

Fair Value
$23.66
Estimated upside 9.5%
Valuation Rating
Undervalued
Estimated upside of 9.5%
Analyst Target
$36.06
Implied upside 67.0%
Financial Health
Weak
Current financial-health read

The current fair value estimate for Denali Therapeutics Inc (NASDAQ-DNLI) is $23.66. This implies an estimated upside of 9.5% versus the current market price.

Based on the current fair value estimate, the stock appears undervalued, with estimated upside of 9.5% versus the current market price.

The available analyst price target for Denali Therapeutics Inc (NASDAQ-DNLI) is $36.06. The analyst target implies estimated upside of 67.0%.

The current financial health read for Denali Therapeutics Inc (NASDAQ-DNLI) is Weak. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Denali Therapeutics Inc (NASDAQ-DNLI) is November 11, 2026.

The latest available data indicates no current dividend yield for Denali Therapeutics Inc (NASDAQ-DNLI).

The current market capitalization listed for Denali Therapeutics Inc is 3.453 B.

The current enterprise value listed for Denali Therapeutics Inc is 2.37 B. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Denali Therapeutics Inc is NASDAQ-DNLI, and the stock is listed on NASDAQ.

Denali Therapeutics Inc (NASDAQ-DNLI) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Denali Therapeutics Inc is 1.1%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Denali Therapeutics Inc is 97.0%. Free float helps investors understand how much of the share base is available for public trading.