Spero Therapeutics Inc (SPRO)

Spero Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing treatments for multidrug-resistant bacterial infections and certain rare diseases in the United States. Its pipeline includes tebipenem HBr, an oral carbapenem antibiotic in Phase 3 development for complicated urinary tract infections, including pyelonephritis in adults, and SPR720, a candidate being developed for first-line treatment of nontuberculous mycobacterial pulmonary disease. The company also has collaboration and license arrangements with Meiji Seika Pharma Co., Ltd. for tebipenem HBr, Everest Medicines for SPR206 in Greater China, South Korea, and Southeast Asia, and Vertex Pharmaceuticals Incorporated covering patents related to SPR720 and SPR719. Spero Therapeutics was founded in 2013 and is headquartered in Cambridge, Massachusetts.


Jump directly to the stock analysis sections supported by the latest available data.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Dividend Yield Next Earnings Date P/E Ratio Price-to-Book Ratio Price-to-Sales Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Free Cash Flow / Net Income
NASDAQ-SPRO
$1.30
-4.4% Downside
Fair
$5
267.6% Upside
Bargain
Great
0.0%
November 16, 2026
10.7x
1.8x
1.7x
79.199 M
30.468 M
2.6%
80.2%
-4.7
265.2%
Valuation • Fair Value

Spero Therapeutics Inc (NASDAQ-SPRO) Fair Value by Valuation Model

Review the available estimates for Spero Therapeutics Inc (NASDAQ-SPRO), including Ben Graham Formula Value, Comps Fair Value.

Primary Valuation Read

Fair Value

$1.30

Estimated downside of 4.4% versus the current market price.

Fair Value Confidence

Med

Confidence level for the primary fair value estimate.

Ben Graham Formula Value

$1.41

Classic Ben Graham valuation formula reference.

Comps Fair Value

$1.30

Comparable-company valuation reference.

Analyst Price Target

$5

Analysts imply upside of 267.6%.

How to read these valuation models

Use the 5 available valuation references for Spero Therapeutics Inc (NASDAQ-SPRO) as analytical inputs, not a standalone conclusion. Valuation methods can differ because they rely on different assumptions, time horizons and financial inputs; compare the estimates with the current price and the company’s financial quality.

Profitability • Growth

Profitability & Growth for Spero Therapeutics Inc (NASDAQ-SPRO)

Review the profitability and growth indicators currently supported by the latest data.

Revenue

46.997 M

Current operating scale indicator.

Revenue Forecast

258 K

Forward revenue estimate.

EBITDA

0 K

Current operating profitability reference.

EBITDA Forecast

-66.74 K

Forward operating profitability estimate.

How to read profitability and growth

This section helps investors review Spero Therapeutics Inc (NASDAQ-SPRO) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Spero Therapeutics Inc (NASDAQ-SPRO)

Review the financial quality and risk indicators currently supported by the latest data.

Financial Health

Great

Positive financial-health read.

Piotroski Score

8

Relatively strong quality score.

Altman Z-Score

-4.7

Lower score that deserves closer risk review.

FCF / Net Income

265.2%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Spero Therapeutics Inc (NASDAQ-SPRO). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Spero Therapeutics Inc (NASDAQ-SPRO)

Track the upcoming dates and dividend metrics currently supported by the latest data.

Next Earnings Date

November 16, 2026

Days to Earnings

55

Dividend Yield

0.0%

No current dividend yield is indicated.

How to read events and dividends

This section helps investors track time-sensitive items for Spero Therapeutics Inc (NASDAQ-SPRO), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Spero Therapeutics Inc (NASDAQ-SPRO) Stock Forecast & Technical Outlook

Review Spero Therapeutics Inc (NASDAQ-SPRO) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Strong Buy

The 15-minute technical read for Spero Therapeutics Inc (NASDAQ-SPRO) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Strong Buy

The 1-hour technical read for Spero Therapeutics Inc (NASDAQ-SPRO) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Strong Buy

The daily technical read for Spero Therapeutics Inc (NASDAQ-SPRO) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Strong Sell

The weekly technical read for Spero Therapeutics Inc (NASDAQ-SPRO) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Strong Sell

The monthly technical read for Spero Therapeutics Inc (NASDAQ-SPRO) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Spero Therapeutics Inc (NASDAQ-SPRO)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Buy

Based on the available recommendation mix, Spero Therapeutics Inc (NASDAQ-SPRO) has a Buy consensus, with 1 buy, 1 hold and 0 sell recommendations in the current data set.

Buy 1
Hold 1
Sell 0
FAQ Fast Investor Answers

Spero Therapeutics Inc (NASDAQ-SPRO) Stock FAQ

Data-supported answers about Spero Therapeutics Inc (NASDAQ-SPRO), including explicit coverage status where a reliable valuation estimate is not currently available.

Fair Value
$1.30
Estimated downside 4.4%
Valuation Rating
Overvalued
Estimated downside of 4.4%
Analyst Target
$5
Implied upside 267.6%
Financial Health
Great
Current financial-health read

The current fair value estimate for Spero Therapeutics Inc (NASDAQ-SPRO) is $1.30. This implies an estimated downside of 4.4% versus the current market price.

Based on the current fair value estimate, the stock appears overvalued, with estimated downside of 4.4% versus the current market price.

The available analyst price target for Spero Therapeutics Inc (NASDAQ-SPRO) is $5. The analyst target implies estimated upside of 267.6%.

The current financial health read for Spero Therapeutics Inc (NASDAQ-SPRO) is Great. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Spero Therapeutics Inc (NASDAQ-SPRO) is November 16, 2026.

The latest available data indicates no current dividend yield for Spero Therapeutics Inc (NASDAQ-SPRO).

The current P/E ratio listed for Spero Therapeutics Inc (NASDAQ-SPRO) is 10.7x. Use it together with growth, margins and sector comparisons rather than as a standalone valuation signal.

The current market capitalization listed for Spero Therapeutics Inc is 79.199 M.

The current enterprise value listed for Spero Therapeutics Inc is 30.468 M. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Spero Therapeutics Inc is NASDAQ-SPRO, and the stock is listed on NASDAQ.

Spero Therapeutics Inc (NASDAQ-SPRO) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Spero Therapeutics Inc is 2.6%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Spero Therapeutics Inc is 80.2%. Free float helps investors understand how much of the share base is available for public trading.