Inhibikase Therapeutics Inc (IKT)

Inhibikase Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing therapies intended to alter the course of cardiopulmonary diseases, with an emphasis on pulmonary arterial hypertension (PAH). The company’s lead program, IKT-001, is an oral prodrug of imatinib mesylate being developed for PAH with the aim of preserving systemic exposure and efficacy while improving tolerability. According to the company, IKT-001 has completed non-human primate safety work and a bioequivalence study in healthy volunteers, which showed dose equivalence with imatinib. The program is now under evaluation in the global adaptive Phase 3 IMPROVE-PAH trial, which includes measures such as pulmonary vascular resistance and 6-minute walk distance. Inhibikase Therapeutics also has an exclusive license for IKT-001 and previously entered into a collaborative research and development agreement with Sphaera Pharma Pte. Ltd., later assigned to Pivot Holding LLC. The company was founded in 2008 and is headquartered in Wilmington, Delaware.

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