Silence Therapeutics PLC (SLN)

Silence Therapeutics plc is a biotechnology company whose Nasdaq-listed security is an American depositary receipt representing common stock. The company focuses on discovering and developing RNA interference, or siRNA, molecules designed to reduce the expression of specific target genes. Its research programs span hematology, cardiovascular disease, and rare diseases. The pipeline includes Divesiran (SLN124), which is in Phase 2 development for polycythemia vera, as well as SLN548 for complement-mediated renal diseases. Additional candidates include Zerlasiran (SLN360) for cardiovascular disease linked to elevated lipoprotein(a), SLN312 for dyslipidemia, SLN365 for hypercholesterolemia, and SLN098 for obesity. Incorporated in 1994, the company was previously known as SR Pharma plc and adopted its current name in May 2007. Silence Therapeutics is headquartered in London, United Kingdom.


Jump directly to the stock analysis sections supported by the latest available data.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Dividend Yield Next Earnings Date Price-to-Book Ratio Price-to-Sales Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Free Cash Flow / Net Income
NASDAQ-SLN
$10.09
-17.9% Downside
Fair
$33
168.5% Upside
Bargain
Fair
0.0%
November 17, 2026
19.2x
1,199.3x
740 M
665.6 M
0.0%
80.1%
-15.3
70.5%
Valuation • Fair Value

Silence Therapeutics PLC (NASDAQ-SLN) Fair Value by Valuation Model

Review the available estimates for Silence Therapeutics PLC (NASDAQ-SLN), including DCF Fair Value, Comps Fair Value.

Primary Valuation Read

Fair Value

$10.09

Estimated downside of 17.9% versus the current market price.

Fair Value Confidence

Low

Confidence level for the primary fair value estimate.

DCF Fair Value

$18.38

Discounted cash flow valuation reference.

Comps Fair Value

$7.32

Comparable-company valuation reference.

Analyst Price Target

$33

Analysts imply upside of 168.5%.

How to read these valuation models

Use the 5 available valuation references for Silence Therapeutics PLC (NASDAQ-SLN) as analytical inputs, not a standalone conclusion. Valuation methods can differ because they rely on different assumptions, time horizons and financial inputs; compare the estimates with the current price and the company’s financial quality.

Profitability • Growth

Profitability & Growth for Silence Therapeutics PLC (NASDAQ-SLN)

Review the profitability and growth indicators currently supported by the latest data.

Revenue

615 K

Current operating scale indicator.

Revenue Forecast

395.6 K

Forward revenue estimate.

EBITDA

-63.942 M

Current operating profitability reference.

EBITDA Forecast

-59.613 M

Forward operating profitability estimate.

How to read profitability and growth

This section helps investors review Silence Therapeutics PLC (NASDAQ-SLN) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Silence Therapeutics PLC (NASDAQ-SLN)

Review the financial quality and risk indicators currently supported by the latest data.

Financial Health

Fair

Mixed or neutral financial-health read.

Piotroski Score

2

Weak quality score that deserves closer review.

Beneish M-Score

-9.62

No elevated caution signal from this screen.

Altman Z-Score

-15.3

Lower score that deserves closer risk review.

FCF / Net Income

70.5%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Silence Therapeutics PLC (NASDAQ-SLN). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Silence Therapeutics PLC (NASDAQ-SLN)

Track the upcoming dates and dividend metrics currently supported by the latest data.

Next Earnings Date

November 17, 2026

Days to Earnings

56

Dividend Yield

0.0%

No current dividend yield is indicated.

How to read events and dividends

This section helps investors track time-sensitive items for Silence Therapeutics PLC (NASDAQ-SLN), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Silence Therapeutics PLC (NASDAQ-SLN) Stock Forecast & Technical Outlook

Review Silence Therapeutics PLC (NASDAQ-SLN) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Strong Sell

The 15-minute technical read for Silence Therapeutics PLC (NASDAQ-SLN) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Neutral

The 1-hour technical read for Silence Therapeutics PLC (NASDAQ-SLN) is currently Neutral. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Strong Sell

The daily technical read for Silence Therapeutics PLC (NASDAQ-SLN) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Strong Buy

The weekly technical read for Silence Therapeutics PLC (NASDAQ-SLN) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Strong Buy

The monthly technical read for Silence Therapeutics PLC (NASDAQ-SLN) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Silence Therapeutics PLC (NASDAQ-SLN)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Strong Buy

Based on the available recommendation mix, Silence Therapeutics PLC (NASDAQ-SLN) has a Strong Buy consensus, with 5 buy, 0 hold and 1 sell recommendations in the current data set.

Buy 5
Hold 0
Sell 1
FAQ Fast Investor Answers

Silence Therapeutics PLC (NASDAQ-SLN) Stock FAQ

Data-supported answers about Silence Therapeutics PLC (NASDAQ-SLN), including explicit coverage status where a reliable valuation estimate is not currently available.

Fair Value
$10.09
Estimated downside 17.9%
Valuation Rating
Overvalued
Estimated downside of 17.9%
Analyst Target
$33
Implied upside 168.5%
Financial Health
Fair
Current financial-health read

The current fair value estimate for Silence Therapeutics PLC (NASDAQ-SLN) is $10.09. This implies an estimated downside of 17.9% versus the current market price.

Based on the current fair value estimate, the stock appears overvalued, with estimated downside of 17.9% versus the current market price.

The available analyst price target for Silence Therapeutics PLC (NASDAQ-SLN) is $33. The analyst target implies estimated upside of 168.5%.

The current financial health read for Silence Therapeutics PLC (NASDAQ-SLN) is Fair. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Silence Therapeutics PLC (NASDAQ-SLN) is November 17, 2026.

The latest available data indicates no current dividend yield for Silence Therapeutics PLC (NASDAQ-SLN).

The current market capitalization listed for Silence Therapeutics PLC is 740 M.

The current enterprise value listed for Silence Therapeutics PLC is 665.6 M. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Silence Therapeutics PLC is NASDAQ-SLN, and the stock is listed on NASDAQ.

Silence Therapeutics PLC (NASDAQ-SLN) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Silence Therapeutics PLC is 0.0%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Silence Therapeutics PLC is 80.1%. Free float helps investors understand how much of the share base is available for public trading.