Spruce Biosciences Inc (SPRB)

Spruce Biosciences, Inc. is a biopharmaceutical company developing therapies for neurological disorders and other serious rare diseases. Its pipeline includes TA-ERT, an enzyme replacement therapy candidate for Sanfilippo Syndrome Type B, as well as Tildacerfont, which is being studied for a severe mental disorder marked by depressed mood and related cognitive, emotional, and physical symptoms. The company is also advancing SPR202 for Congenital Adrenal Hyperplasia, a chronic rare disease with no cure. Spruce Biosciences has a license agreement with Eli Lilly and Company covering research, development, and commercialization of certain pharmaceutical compounds, and a collaboration with Kaken Pharmaceutical Co. Ltd. focused on Tildacerfont for CAH in Japan. Incorporated in 2014, the company is headquartered in South San Francisco, California.


Jump directly to the stock analysis sections supported by the latest available data.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Dividend Yield Next Earnings Date Price-to-Book Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Free Cash Flow / Net Income
NASDAQ-SPRB
$55.20
10.4% Upside
Fair
$148
196.1% Upside
Bargain
Fair
0.0%
November 16, 2026
1.8x
143.7 M
65.711 M
4.7%
70.2%
0.3
83.3%
Valuation • Fair Value

Spruce Biosciences Inc (NASDAQ-SPRB) Fair Value by Valuation Model

Review the available estimates for Spruce Biosciences Inc (NASDAQ-SPRB), including Comps Fair Value.

Primary Valuation Read

Fair Value

$55.20

Estimated upside of 10.4% versus the current market price.

Fair Value Confidence

Very low

Confidence level for the primary fair value estimate.

Comps Fair Value

$55.20

Comparable-company valuation reference.

Analyst Price Target

$148

Analysts imply upside of 196.1%.

How to read these valuation models

Use the 4 available valuation references for Spruce Biosciences Inc (NASDAQ-SPRB) as analytical inputs, not a standalone conclusion. Valuation methods can differ because they rely on different assumptions, time horizons and financial inputs; compare the estimates with the current price and the company’s financial quality.

Profitability • Growth

Profitability & Growth for Spruce Biosciences Inc (NASDAQ-SPRB)

Review the profitability and growth indicators currently supported by the latest data.

Revenue Forecast

0 K

Forward revenue estimate.

EBITDA

-39.037 M

Current operating profitability reference.

How to read profitability and growth

This section helps investors review Spruce Biosciences Inc (NASDAQ-SPRB) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Spruce Biosciences Inc (NASDAQ-SPRB)

Review the financial quality and risk indicators currently supported by the latest data.

Financial Health

Fair

Mixed or neutral financial-health read.

Piotroski Score

5

Mid-range quality score.

Altman Z-Score

0.3

Lower score that deserves closer risk review.

FCF / Net Income

83.3%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Spruce Biosciences Inc (NASDAQ-SPRB). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Spruce Biosciences Inc (NASDAQ-SPRB)

Track the upcoming dates and dividend metrics currently supported by the latest data.

Next Earnings Date

November 16, 2026

Days to Earnings

55

Dividend Yield

0.0%

No current dividend yield is indicated.

How to read events and dividends

This section helps investors track time-sensitive items for Spruce Biosciences Inc (NASDAQ-SPRB), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Spruce Biosciences Inc (NASDAQ-SPRB) Stock Forecast & Technical Outlook

Review Spruce Biosciences Inc (NASDAQ-SPRB) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Strong Sell

The 15-minute technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Strong Sell

The 1-hour technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Strong Sell

The daily technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Sell

The weekly technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Sell

The monthly technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Spruce Biosciences Inc (NASDAQ-SPRB)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Strong Buy

Based on the available recommendation mix, Spruce Biosciences Inc (NASDAQ-SPRB) has a Strong Buy consensus, with 8 buy, 0 hold and 0 sell recommendations in the current data set.

Buy 8
Hold 0
Sell 0
FAQ Fast Investor Answers

Spruce Biosciences Inc (NASDAQ-SPRB) Stock FAQ

Data-supported answers about Spruce Biosciences Inc (NASDAQ-SPRB), including explicit coverage status where a reliable valuation estimate is not currently available.

Fair Value
$55.20
Estimated upside 10.4%
Valuation Rating
Undervalued
Estimated upside of 10.4%
Analyst Target
$148
Implied upside 196.1%
Financial Health
Fair
Current financial-health read

The current fair value estimate for Spruce Biosciences Inc (NASDAQ-SPRB) is $55.20. This implies an estimated upside of 10.4% versus the current market price.

Based on the current fair value estimate, the stock appears undervalued, with estimated upside of 10.4% versus the current market price.

The available analyst price target for Spruce Biosciences Inc (NASDAQ-SPRB) is $148. The analyst target implies estimated upside of 196.1%.

The current financial health read for Spruce Biosciences Inc (NASDAQ-SPRB) is Fair. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Spruce Biosciences Inc (NASDAQ-SPRB) is November 16, 2026.

The latest available data indicates no current dividend yield for Spruce Biosciences Inc (NASDAQ-SPRB).

The current market capitalization listed for Spruce Biosciences Inc is 143.7 M.

The current enterprise value listed for Spruce Biosciences Inc is 65.711 M. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Spruce Biosciences Inc is NASDAQ-SPRB, and the stock is listed on NASDAQ.

Spruce Biosciences Inc (NASDAQ-SPRB) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Spruce Biosciences Inc is 4.7%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Spruce Biosciences Inc is 70.2%. Free float helps investors understand how much of the share base is available for public trading.