Spruce Biosciences Inc (SPRB)

Spruce Biosciences, Inc. is a biopharmaceutical company developing therapies for neurological disorders and other serious rare diseases. Its pipeline includes TA-ERT, an enzyme replacement therapy candidate for Sanfilippo Syndrome Type B, as well as Tildacerfont, which is being studied for a severe mental disorder marked by depressed mood and related cognitive, emotional, and physical symptoms. The company is also advancing SPR202 for Congenital Adrenal Hyperplasia, a chronic rare disease with no cure. Spruce Biosciences has a license agreement with Eli Lilly and Company covering research, development, and commercialization of certain pharmaceutical compounds, and a collaboration with Kaken Pharmaceutical Co. Ltd. focused on Tildacerfont for CAH in Japan. Incorporated in 2014, the company is headquartered in South San Francisco, California.


Jump between the core stock analysis sections, valuation data, fair value models, technical outlook, and FAQ.

Data update note: Fair value and stock analysis metrics are updated after regular market sessions when new data becomes available.
Ticker Fair Value Fair Value Upside/Downside Fair Value Rating Analyst Price Target Analyst Target Upside/Downside Analyst Target Rating Overall Financial Health Upcoming Dividend Ex-Date Dividend Payment Date Upcoming Dividend Dividend Yield Next Earnings Date P/E Ratio Price-to-Book Ratio Price-to-Sales Ratio Market Cap Enterprise Value Total Debt / Total Capital Free Float / Shares Outstanding Altman Z-Score Payout Ratio Free Cash Flow / Net Income
NASDAQ-SPRB
$42.52
-6.0% Downside
Fair
$151
233.9% Upside
Bargain
Fair
0.0%
August 12, 2026
-3.4x
3.6x
122.5 M
78.188 M
5.5%
96.4%
-4.7
78.9%
Valuation • Fair Value

Spruce Biosciences Inc (NASDAQ-SPRB) Fair Value by Valuation Model

Compare the primary fair value estimate for Spruce Biosciences Inc (NASDAQ-SPRB) with model-based valuation references such as DCF, Ben Graham, DDM, EPV and comparable-company valuation.

Primary Valuation Read

Fair Value

$42.52

Estimated downside of 6.0% versus the current market price.

Fair Value Confidence

Very low

Confidence level for the primary fair value estimate.

DCF Fair Value

NM

Discounted cash flow valuation reference.

Ben Graham Formula Value

$0

Classic Ben Graham valuation formula reference.

DDM Fair Value

NM

Dividend discount model valuation reference.

EPV Fair Value

NM

Earnings power value estimate.

Comps Fair Value

$42.52

Comparable-company valuation reference.

Analyst Price Target

$151

Analysts imply upside of 233.9%.

How to read these valuation models

Use this section to compare the primary fair value estimate for Spruce Biosciences Inc (NASDAQ-SPRB) with several model-based valuation references. Different models can produce different outputs because each method relies on a different set of assumptions, so the primary fair value estimate should be read alongside the model spread rather than in isolation.

Profitability • Growth

Profitability & Growth for Spruce Biosciences Inc (NASDAQ-SPRB)

A compact read on revenue, forward revenue expectations, EBITDA and operating profitability trends.

Revenue

Not available

Data is currently unavailable.

Revenue Forecast

0 K

Forward revenue estimate.

EBITDA

-25.841 M

Current operating profitability reference.

EBITDA Forecast

Not available

Data is currently unavailable.

How to read profitability and growth

This section helps investors review Spruce Biosciences Inc (NASDAQ-SPRB) from an operating perspective by combining current scale, forward revenue expectations and EBITDA-related profitability measures.

Quality • Risk

Quality & Financial Risk for Spruce Biosciences Inc (NASDAQ-SPRB)

Review financial health, earnings quality and balance-sheet risk through Piotroski, Beneish, Altman and cash conversion metrics.

Financial Health

Fair

Mixed or neutral financial-health read.

Piotroski Score

4

Mid-range quality score.

Beneish M-Score

NM

Forensic accounting screen.

Altman Z-Score

-4.7

Lower score that deserves closer risk review.

FCF / Net Income

78.9%

Cash conversion quality indicator.

How to read quality and risk

This section combines quality, balance-sheet and accounting-risk indicators for Spruce Biosciences Inc (NASDAQ-SPRB). Read the metrics together: no single score is a complete investment conclusion, but the combined view can highlight financial strength, earnings quality and areas that may deserve closer review.

Events • Dividends

Upcoming Events & Dividends for Spruce Biosciences Inc (NASDAQ-SPRB)

Track the next earnings date, ex-dividend date, dividend payment date, dividend yield and upcoming distribution details where available.

Next Earnings Date

August 12, 2026

Days to Earnings

22

Dividend Payment Date

Not available

Ex-Dividend Date

Not available

Dividend Yield

0.0%

Income yield reference.

Upcoming Dividend

Not available

Data is currently unavailable.

Payment Type

Not available

Data is currently unavailable.

Dividend Currency

Not available

Data is currently unavailable.

Payout Ratio

Not available

Data is currently unavailable.

How to read events and dividends

This section helps investors track time-sensitive items for Spruce Biosciences Inc (NASDAQ-SPRB), including the next earnings date and dividend-related milestones. These items can matter for short-term volatility, income planning and event-driven positioning.

Stock Forecast • Technical Outlook

Spruce Biosciences Inc (NASDAQ-SPRB) Stock Forecast & Technical Outlook

Review Spruce Biosciences Inc (NASDAQ-SPRB) across multiple technical time frames, alongside analyst recommendation data, to form a faster read on market positioning and near-term sentiment.

Technical Signals by Time Frame

Switch between time frames to review the current technical signal for the stock.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 15-minute • intraday
Strong Buy

The 15-minute technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: 1-hour • short-term
Buy

The 1-hour technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Buy. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: daily • daily
Strong Sell

The daily technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: weekly • weekly
Strong Sell

The weekly technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Strong Sell Sell Neutral Buy Strong Buy
Time frame: monthly • monthly
Strong Sell

The monthly technical read for Spruce Biosciences Inc (NASDAQ-SPRB) is currently Strong Sell. Use it as a timing signal only, and compare it with valuation, fundamentals and upcoming events before drawing a broader view.

Analyst Consensus for Spruce Biosciences Inc (NASDAQ-SPRB)

A consolidated view of buy, hold and sell recommendations based on the currently available analyst data.

Strong Sell Sell Neutral Buy Strong Buy
Consolidated analyst recommendation mix
Strong Buy

Based on the available recommendation mix, Spruce Biosciences Inc (NASDAQ-SPRB) has a Strong Buy consensus, with 7 buy, 0 hold and 0 sell recommendations in the current data set.

Buy 7
Hold 0
Sell 0
FAQ Fast Investor Answers

Spruce Biosciences Inc (NASDAQ-SPRB) Stock FAQ

Quick answers about Spruce Biosciences Inc (NASDAQ-SPRB) stock, including fair value, valuation rating, analyst price target, dividends, earnings dates, market capitalization, financial health and other key stock analysis metrics.

Fair Value
$42.52
Estimated downside 6.0%
Valuation Rating
Overvalued
Estimated downside of 6.0%
Analyst Target
$151
Implied upside 233.9%
Financial Health
Fair
Current financial-health read

The current fair value estimate for Spruce Biosciences Inc (NASDAQ-SPRB) is $42.52. This implies an estimated downside of 6.0% versus the current market price.

Based on the current fair value estimate, the stock appears overvalued, with estimated downside of 6.0% versus the current market price.

The available analyst price target for Spruce Biosciences Inc (NASDAQ-SPRB) is $151. The analyst target implies estimated upside of 233.9%.

The current financial health read for Spruce Biosciences Inc (NASDAQ-SPRB) is Fair. This should be reviewed alongside valuation, profitability, debt and cash-flow quality metrics.

The next earnings date currently listed for Spruce Biosciences Inc (NASDAQ-SPRB) is August 12, 2026.

Based on the current data, dividend yield is 0.0%.

The current P/E ratio listed for Spruce Biosciences Inc (NASDAQ-SPRB) is -3.4x. Use it together with growth, margins and sector comparisons rather than as a standalone valuation signal.

The current market capitalization listed for Spruce Biosciences Inc is 122.5 M.

The current enterprise value listed for Spruce Biosciences Inc is 78.188 M. Enterprise value can provide a broader valuation view than market capitalization alone because it also considers net debt.

The ticker symbol for Spruce Biosciences Inc is NASDAQ-SPRB, and the stock is listed on NASDAQ.

Spruce Biosciences Inc (NASDAQ-SPRB) is listed on NASDAQ.

The current debt-to-total-capital ratio listed for Spruce Biosciences Inc is 5.5%, which helps investors evaluate the company’s financing structure and leverage profile.

The free float listed for Spruce Biosciences Inc is 96.4%. Free float helps investors understand how much of the share base is available for public trading.